Free Molecular And Genome Evolution Ebooks Online
This book describes the driving forces behind the evolutionary process at the molecular and genome levels, the effects of the various molecular mechanisms on the structure of genes, proteins, and genomes.
Hardcover: 612 pages
Publisher: Sinauer Associates, Inc.; 1st edition (January 4, 2016)
Language: English
ISBN-10: 1605354694
ISBN-13: 978-1605354699
Product Dimensions: 1.2 x 9.2 x 11.8 inches
Shipping Weight: 1.6 pounds (View shipping rates and policies)
Average Customer Review: 5.0 out of 5 stars See all reviews (1 customer review)
Best Sellers Rank: #611,037 in Books (See Top 100 in Books) #138 in Books > Computers & Technology > Computer Science > Bioinformatics #625 in Books > Engineering & Transportation > Engineering > Bioengineering > Biochemistry #2934 in Books > Science & Math > Evolution
Dan Graur has written a masterly account of molecular and genome evolution, and I expect to be getting more and more from it as I re-read and refer to it. As anyone who follows his blog Judge Starling (dan = judge in Hebrew, graur = starling in Roumanian) will know, he is not someone to be discreet about his opinions. His often expressed contempt for the ENCODE project, which cost around $300000 to arrive at the claim that the great majority of the human genome is “functional” makes his blog worth reading for that alone.As well as explaining protein, nucleic acid structure, mutations and so on in the early chapters, Graur explains in some detail how phylogenetic trees are constructed from molecular data., describing, for example, the simplest method, UPGMA, as well as others such as the widely used computational method, CLUSTAL.He is not frightened of giving the mathematical basis for his analyses, and assumes that his readers will not be, either. It would be an exaggeration to say that the mathematics is trivial or very simple, but little of it should be beyond the reach of readers who make the effort.I was particularly interested in his calculation that if 80% of the genome is functional, as claimed, then each of us must have at least 30,000,000,000,000,000,000 children if the population is to avoid collapsing from lethal mutations. As he rightly says, this result is “bonkers”, but there is nothing wrong with the calculation, so the starting point cannot be right. He believes, as I do, that most mutations are neutral, and that the human population can easily avoid collapsing from the genetic load represented by the few that are not.
Molecular and Genome Evolution Power Laws, Scale-Free Networks and Genome Biology (Molecular Biology Intelligence Unit) Molecular Biology: Principles of Genome Function Cellular and Molecular Immunology, 8e (Cellular and Molecular Immunology, Abbas) The $1,000 Genome: The Revolution in DNA Sequencing and the New Era of Personalized Medicine Genome-Scale Algorithm Design: Biological Sequence Analysis in the Era of High-Throughput Sequencing Genome: The Autobiography of a Species in 23 Chapters The Spiritual Genome (Middle English Edition) Vitamin D: Physiology, Molecular Biology, and Clinical Applications (Nutrition and Health) Computational Chemistry: Introduction to the Theory and Applications of Molecular and Quantum Mechanics Histology: A Text and Atlas: With Correlated Cell and Molecular Biology Histology: A Text and Atlas, with Correlated Cell and Molecular Biology, 6th Edition Histology: A Text and Atlas: With Correlated Cell and Molecular Biology (Histology (Ross)) Biological Modeling and Simulation: A Survey of Practical Models, Algorithms, and Numerical Methods (Computational Molecular Biology) BRS Biochemistry, Molecular Biology, and Genetics (Board Review Series) The Neuron: Cell and Molecular Biology Fish Swimming (Molecular and Cell Biochemistry) Molecular Diagnostics: Fundamentals, Methods and Clinical Applications Biochemical, Physiological, and Molecular Aspects of Human Nutrition, 3e Cell and Molecular Biology (Lippincott Illustrated Reviews Series)
